کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8418698 1545725 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Area under the curve as a tool to measure kinetics of tumor growth in experimental animals
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Area under the curve as a tool to measure kinetics of tumor growth in experimental animals
چکیده انگلیسی
Measurement of tumor diameters or tumor volumes has been traditionally used to quantitate and compare tumor growth curves in mice and rats. Here, we describe the use of area under the curve (AUC) as an alternative method to do the same. This single numerical value (a) is easy to obtain for individual curves, (b) reflects the entire tumor growth curve through a single number, (c) can be easily modified to obtain data for defined sections of the growth curve (for example, to determine stable disease), and (d) allows easier comparisons between groups. Using tumor growth data from a large number of mice challenged with live tumor cells, we demonstrate the utility of this tool over the conventional methods for these purposes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Immunological Methods - Volume 382, Issues 1–2, 31 August 2012, Pages 224-228
نویسندگان
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