Development of a high-sensitivity latex reagent for the detection of C-reactive protein

► We introduced spacer amino acids in the latex surface and produced latex reagents. ► We investigated the relationship between the amino acid and the binding of an antibody. ► The reactivity depends on the inorganicity and organicity of the amino acid side chain. ► An inorganicity-to-organicity ratio of approximately 2 is useful for an amino acid spacer.