Using T. brucei as a biological epitope-display platform to elicit specific antibody responses

► The African trypanosome can be used as a novel immunogenic display platform. ► Trypanosomes can be engineered to display exogenous epitopes on their surface coat. ► Fixed trypanosomes with engineered surface coats can elicit specific antisera to the exogenous epitope. ► Engineered trypanosomes can be used as an alternative approach to generating anti-peptide antisera.