کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8426436 | 1546051 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Postponement of canine puberty by neonatal administration of a long term release GnRH superagonist
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
The objective of this study was to assess the efficiency and clinical safety of postnatal administration of a GnRH agonist on canine puberty postponement. Sexual steroids and histological gonadal changes were also described. Twenty-four littermate puppies were randomly assigned to: Deslorelin acetate 18.8â¯mg sc (DESLO; nâ¯=â¯12) or Placebo: sc (PLACE; nâ¯=â¯12) postnatally. The dogs were clinically and endocrinologically followed up until puberty when they were gonadectomized and their gonads histomorphometrically studied. Deslorelin postponed the age of puberty (72.7â¯Â±â¯4.8 vs. 35.8â¯Â±â¯1.9 weeks; Pâ¯<â¯0.01) in these dogs. At the time of this submission, 3 DESLO dogs (108 weeks old) remain non-pubertal. All dogs concluded growing at a similar age (29.75â¯Â±â¯2.44 vs. 29.25â¯Â±â¯0.90 weeks; Pâ¯>â¯0.1) independently of their group and pubertal status. None of the females had side effects while the 2 non pubertal DESLO males presented bilateral cryptorchydism. All the bitches ovulated at puberty (Pâ¯>â¯0.1) and the 2 DESLO that were mated became pregnant. Deslorelin postponed basal serum sexual steroids up to puberty in both genders (Pâ¯<â¯0.01). The histomorphometrical study of the testes revealed that the tubular diameter (Pâ¯<â¯0.05), germinal epithelium height and composition (Pâ¯<â¯0.01) were decreased in DESLO group. Ovarian structures did not differ between treatments (Pâ¯>â¯0.05). It was concluded that postnatal deslorelin decreased sexual steroids reversibly postponing puberty in both genders without side effects in bitches and causing 2/6 of cryptorchydism and impairment of testicular histomorphometry in male dogs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Theriogenology - Volume 118, 15 September 2018, Pages 190-195
Journal: Theriogenology - Volume 118, 15 September 2018, Pages 190-195
نویسندگان
M. Faya, C. Marchetti, M. Priotto, M. GrisolÃa, F. D'Francisco, C. Gobello,