کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8427378 1546059 2018 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Contractile effect of rifaximin on bovine uterus in the presence of steroid hormone antagonists
ترجمه فارسی عنوان
اثر متقابل ریفکسی مین بر رحم گاو در حضور آنتاگونیست های هورمون استروئید
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی
This in vitro study investigated the modulatory effect of rifaximin on bovine uterus contractility, in both phases of the oestrous cycle, with and without the steroid hormones that are predominant in the respective phases: oestrogen in the follicular phase and progesterone in the luteal phase. The procedures were conducted in an isolated organ bath by using rifaximin alone (10−4 M) and in association with the steroid hormone antagonists (10−5 M) tamoxifen (oestrogen antagonist) in the follicular phase and mifepristone (progesterone antagonist) in the luteal phase. The results indicated that rifaximin can stimulate uterine contractility. Indeed, the administration of rifaximin in the presence of tamoxifen or mifepristone increased the tonic activity of the uterus in both phases of the cycle. This result is clinically significant because rifaximin might also enable, in vivo, a simultaneous increase in uterine cleaning and the antimicrobial action against bacteria during the first 14 days postpartum, during the development of acute metritis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Theriogenology - Volume 110, 1 April 2018, Pages 74-78
نویسندگان
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