کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8434437 1546644 2018 28 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Squalene epoxidase as a promising metabolic target in cancer treatment
ترجمه فارسی عنوان
اسکالن اپوکیداز به عنوان یک هدف متابولیک امیدبخش در درمان سرطان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Oncogenic alteration of the cholesterol synthesis pathway is a recognized mechanism of metabolic adaptation. In the present review, we focus on squalene epoxidase (SE), one of the two rate-limiting enzymes in cholesterol synthesis, retracing its history since its discovery as an antimycotic target to its description as an emerging metabolic oncogene by amplification with clinical relevance in cancer. We review the published literature assessing the association between SE over-expression and poor prognosis in this disease. We assess the works demonstrating how SE promotes tumor cell proliferation and migration, and displaying evidence of cancer cell demise in presence of human SE inhibitors in in vitro and in vivo models. Taken together, robust scientific evidence has by now accumulated pointing out SE as a promising novel therapeutic target in cancer treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 425, 1 July 2018, Pages 13-20
نویسندگان
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