Sequencing the transcriptional network of androgen receptor in prostate cancer

► The androgen receptor transcriptional network is central to prostate cancer progression. ► Next Generation Sequencing (NGS) technologies enabled targeted detailing and analysis of the AR transcriptional circuitry. ► Novel insights on the AR transcriptional network in prostate cancers were elucidated by recent sequencing efforts. ► Continued development of NGS technologies are likely to bring about future breakthroughs in prostate cancer therapies.