کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8437479 1546871 2018 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ischemia-Reperfusion Injury Reduces Long Term Renal Graft Survival: Mechanism and Beyond
ترجمه فارسی عنوان
آسیب های ایسکمی-رپرفیوئید بقای طولانی مدت کلیه را کاهش می دهد: مکانیسم و ​​فراتر از آن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific inflammatory responses that can result in the loss of kidney graft viability. However, the long-term consequence of IRI on renal grafts survival is uncertain. Here we review clinical evidence and laboratory studies, and elucidate the association between early IRI and later graft loss. Our critical analysis of previous publications indicates that early IRI does contribute to later graft loss through reduction of renal functional mass, graft vascular injury, and chronic hypoxia, as well as subsequent fibrosis. IRI is also known to induce kidney allograft dysfunction and acute rejection, reducing graft survival. Therefore, attempts have been made to substitute traditional preserving solutions with novel agents, yielding promising results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EBioMedicine - Volume 28, February 2018, Pages 31-42
نویسندگان
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