کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8438758 | 1401529 | 2017 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression
ترجمه فارسی عنوان
قرار گرفتن در معرض نور بنفش می تواند یک استراتژی پیشگیرانه علیه پیشرفت مریض باشد
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کلمات کلیدی
نور بنفش نور نور بیرونی، بیرون از خانه، نزدیک بینی طول محوری، انعکاس،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360-400Â nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EBioMedicine - Volume 15, February 2017, Pages 210-219
Journal: EBioMedicine - Volume 15, February 2017, Pages 210-219
نویسندگان
Hidemasa Torii, Toshihide Kurihara, Yuko Seko, Kazuno Negishi, Kazuhiko Ohnuma, Takaaki Inaba, Motoko Kawashima, Xiaoyan Jiang, Shinichiro Kondo, Maki Miyauchi, Yukihiro Miwa, Yusaku Katada, Kiwako Mori, Keiichi Kato, Kinya Tsubota, Hiroshi Goto,