کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8443349 1547118 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma
چکیده انگلیسی
This study describes the first large screening of somatic mutations in SBA using next generation sequencing. The ERBB2 mutation was revealed to be one of the most frequent alterations in SBA with a distribution dependent on tumour location. In most cases ERBB2 mutation was identical (p.L755S). In clinical practice, this may suggest that more than 10% of the patients with SBA could be treated using an anti-ERBB2-targeted agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 50, Issue 10, July 2014, Pages 1740-1746
نویسندگان
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