Childhood acute lymphoblastic leukaemia and birthweight: Insights from a pooled analysis of case-control data from Germany, the United Kingdom and the United States

Our findings demonstrate the importance of looking across the full birthweight spectrum when examining associations with disease risk. The new observation of a deficit of very-low-birthweight cases at all gestations has aetiological and study design implications for future work examining not only the in utero origins of ALL, but also other childhood and adult cancers.