کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8446922 1547180 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radiochemotherapy versus surgery plus radio(chemo)therapy for stage T3/T4 larynx and hypopharynx cancer - Results of a matched-pair analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Radiochemotherapy versus surgery plus radio(chemo)therapy for stage T3/T4 larynx and hypopharynx cancer - Results of a matched-pair analysis
چکیده انگلیسی
The standard treatment for non-metastatic T3/T4 larynx and hypopharynx cancer varies. This study compared definitive radiochemotherapy to surgery followed by radio(chemo)therapy. Forty-four patients treated with radiochemotherapy were matched to 88 patients receiving surgery plus radio(chemo)therapy. Groups were matched 1:2 for eight factors including age, gender, performance status, tumour site, histologic grade, T-/N-category and AJCC stage. Groups were compared for loco-regional control, metastases-free survival, overall survival and toxicity. Two-year loco-regional control rates were 75% after surgery plus radio(chemotherapy) and 66% after radiochemotherapy (p = 0.39). Metastases-free survival rates were 76% and 77%, respectively (p = 0.76). Overall survival rates were 67% and 63%, respectively (p = 0.95). During follow up, 60% and 9% of the patients, respectively, received a total laryngectomy (p = 0.004). Grade ⩾3 oral mucositis and haematologic toxicity rates were higher with radiochemotherapy. Other toxicities were similar. Outcomes of radiochemotherapy appeared similar to those of surgery plus radio(chemo)therapy. The larynx preservation rate was higher after radiochemotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 47, Issue 18, December 2011, Pages 2729-2734
نویسندگان
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