کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8456420 | 1548582 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of repeated dose micronucleus assays of the liver and gastrointestinal tract using potassium bromate: A report of the collaborative study by CSGMT/JEMS.MMS
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of repeated dose micronucleus assays of the liver and gastrointestinal tract using potassium bromate: A report of the collaborative study by CSGMT/JEMS.MMS Evaluation of repeated dose micronucleus assays of the liver and gastrointestinal tract using potassium bromate: A report of the collaborative study by CSGMT/JEMS.MMS](/preview/png/8456420.png)
چکیده انگلیسی
The food additive potassium bromate (KBrO3) is known as a renal carcinogen and causes chromosomal aberrations in vitro without metabolic activation and in vivo in hematopoietic and renal cells. As a part of a collaborative study by the Mammalian Mutagenicity Study group, which is a subgroup of the Japanese Environmental Mutagen Society, we administered KBrO3 to rats orally for 4, 14, and 28 days and examined the micronucleated (MNed) cell frequency in the liver, glandular stomach, colon, and bone marrow to confirm whether the genotoxic carcinogen targeting other than liver and gastrointestinal (GI) tract was detected by the repeated dose liver and GI tract micronucleus (MN) assays. In our study, animals treated with KBrO3 showed some signs of toxicity in the kidney and/or stomach. KBrO3 did not increase the frequency of MNed cells in the liver and colon in any of the repeated dose studies. However, KBrO3 increased the frequency of MNed cells in the glandular stomach and bone marrow. Additionally, the MNed cell frequency in the glandular stomach was not significantly affected by the difference in the length of the administration period. These results suggest that performing the MN assay using the glandular stomach, which is the first tissue to contact agents after oral ingestion, is useful for evaluating the genotoxic potential of chemicals and that the glandular stomach MN assay could be integrated into general toxicity studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volumes 780â781, March 2015, Pages 94-99
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volumes 780â781, March 2015, Pages 94-99
نویسندگان
Emiko Okada, Yohei Fujiishi, Kazunori Narumi, Shoichi Kado, Yumi Wako, Kazufumi Kawasako, Kimiyuki Kaneko, Wakako Ohyama,