Induction of TK mutations in human lymphoblastoid TK6 cells by the rat carcinogen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)

► We examine the mechanism of genotoxicity of MX in human cells. ► MX generates loss of heterozygosity (LOH) in human cells. ► MX may cause the inactivation of tumour suppressor genes by LOH.