Preoperative radiotherapy or chemoradiotherapy in rectal cancer - Is survival improved? An update of the “Nordic” LARC study in non-resectable cancers

The randomized “Nordic” LARC study compared preoperative long-course radiotherapy alone (RT) or with chemotherapy (CRT) in the most locally advanced/ugly rectal cancers. Despite significantly better local control in the CRT group, no overall survival benefit was seen after 10 years follow-up. The relations between local control and survival are discussed.