Heart dose associated with overall survival in locally advanced NSCLC patients treated with hypofractionated chemoradiotherapy

Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V2Gy:HR = 1.007%−1 (95% CI:1.002-1.013; p = 0.006), age:HR = 1.026 year−1 (1.011-1.042; p = 0.001) and GTV volume:HR = 1.001 cc−1 (1.000-1.002; p = 0.006) with overall survival.