کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8462060 | 1549021 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Forskolin-induced differentiation of BeWo cells stimulates increased tumor growth in the chorioallantoic membrane (CAM) of the turkey (Meleagris gallopavo) egg
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Forskolin alone did not have any deleterious effect on the CAM. When the CAM was incubated with BeWo cells cultured in medium 40% of the eggs developed a macroscopically visible tumor. BeWo cells stimulated with forskolin and washed induced tumor growth in 50% of the eggs, while forskolin stimulated BeWo cells applied directly onto the CAM induced tumor growth in 70% of the eggs. Forced differentiation of BeWo cells by forskolin may lead to syncytial fusion in a plastic culture dish. Under the conditions used here, i.e. in direct contact to a living tissue, forskolin-induced differentiation of BeWo cells leads to an increase in tumor formation in the CAM. Thus BeWo cells may use signaling pathways to decide for both differentiation pathways similar to primary trophoblast depending on the environment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 193, Issue 3, May 2011, Pages 220-223
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 193, Issue 3, May 2011, Pages 220-223
نویسندگان
Ralf Schneider, Marcus Borges, Mamed Kadyrov,