کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8463840 | 1549403 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of serum cytokines levels, interleukin 10 â1082G/A and interferon-γ +874T/A polymorphisms with atopic asthma children from Saudi Arabia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 â1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with asthma and 50 age- and gender matched healthy children as controls. The levels of both IL-4 and IL-13 were significantly (p < 0.001) higher, while IFN-γ was significantly (p < 0.001) lower in patients compared to that of the controls. There was a significant effect of gene polymorphisms of IL-10 (p < 0.05) and IFN-γ (p < 0.001) in occurrence of atopic asthma and increased IgE level. Polymorphism of IFN-γ gene had an effect on the serum level of IFN-γ. In conclusion, IFN-γ gene polymorphism at position +874 and IL-10 gene polymorphism at position â1082A/G are genetic determinants which contribute to susceptibility to atopic asthma in children from Saudi Arabia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 289, Issues 1â2, MayâJune 2014, Pages 21-26
Journal: Cellular Immunology - Volume 289, Issues 1â2, MayâJune 2014, Pages 21-26
نویسندگان
Y.M. Hussein, S.S. Alzahrani, A.A. Alharthi, M.M. Ghonaim, A.S. Alhazmi, E.M. Eed, S.M. Shalaby,