کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8463908 1549407 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Temporal analysis of oxidative effects on the pulmonary inflammatory response in mice exposed to cigarette smoke
ترجمه فارسی عنوان
تجزیه و تحلیل موقتی اثرات اکسیداتیو بر پاسخ التهابی ریه در موش هایی که در معرض سیگار قرار می گیرند
کلمات کلیدی
دود سیگار، جریان سیاتومتری، التهاب ریه، استرس اکسیداتیو، موش،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
The most common factor related to the chronic obstructive pulmonary disease (COPD) development is the chronic smoking habit. Our study describes the temporal kinesis of pulmonary cellular influx through BALF analyses of mice acutely exposed to cigarette smoke (CS), the oxidative damage and antioxidative enzyme activities. Thirty-six mice (C57BL/6, 8 weeks old, male) were divided in 6 groups: the control group (CG), exposed to ambient air, and the other 30 mice were exposed to CS. Mice exposed to CS presented, especially after the third day of exposure, different cellular subpopulations in BALF. The oxidative damage was significantly higher in CS exposed groups compared to CG. Our data showed that the evaluated inflammatory cells, observed after three days of CS exposure, indicate that this time point could be relevant to studies focusing on these cellular subpopulation activities and confirm the oxidative stress even in a short term CS exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 284, Issues 1–2, July–August 2013, Pages 29-36
نویسندگان
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