A novel role for the Rho-associated kinase, ROCK, in IL-1-stimulated intestinal epithelial cell responses

► Inhibiting ROCK suppressed IL-1-stimulated secretion and mRNA levels for Caco-2 cell CXCL8 and IEC-6 cell CCL2 responses. ► Suppressing ROCK inhibited IL-1-induced JNK phosphorylation, but had no significant effect on IKK or IκBα responses. ► Suggests a role for ROCK in IL-1-stimulated JNK signaling, but not IKK/IκBα signaling, in intestinal epithelial cells.