Total glucosides of paeony inhibits Th1/Th17 cells via decreasing dendritic cells activation in rheumatoid arthritis

► TGP decreased percentage and number of Th1 and Th17 cells in CIA mice. ► TGP attenuated phosphorylation of STAT1 and STAT3 of T cells from CIA mice. ► TGP inhibited DCs maturation and reduced production of IL-12 and IL-6. ► TGP reduced percentage and number of maturated DCs, Th1 and Th17 in RA patients.