The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells

► Veratric acid negatively regulates iNOS expression in RAW264.7 and BV-2 cells. ► LPS-induced phosphorylation of NF-κB and IκBα is inhibited by veratric acid. ► IFN-γ expression is down-regulated by veratric acid via the inactivation of STAT-1. ► Veratric acid inhibits IL-6 expression, mediated by the inactivation of GSK-3β and STAT-3. ► Veratric acid suppresses the phosphorylation of JNK, ERK1/2, and p38.