Post-transcriptional down-regulation of Toll-like receptor signaling pathway in umbilical cord blood plasmacytoid dendritic cells

► We reveal the post-transcriptional control of IFN-alpha production in cord blood. ► Cord blood plasmacytoid dendritic cells exhibit a profound defect in IFN-a production. ► This defect correlates with the lower expression of proteins within the TLR9 pathway. ► We also observed a higher expression of miR-146a and miR-155. ► Although, cord blood PDC are mature and differentiate in antigen-presenting cells.