CCL5 induces a pro-inflammatory profile in microglia in vitro

► The chemokine receptors CCR1, CCR5, and CXCR2 are functionally expressed in primary rat microglia. ► The chemokines CCL2, CCL3, CCL5, and CXCL1 induce chemotaxis in microglia. ► CCL5 and CCL2 increased NO production in microglia. ► CCL5, but not the other chemokines, attenuated IL-10 and IGF-1 production.