Placenta-derived PLX-PAD mesenchymal-like stromal cells are efficacious in rescuing blood flow in hind limb ischemia mouse model by a dose- and site-dependent mechanism of action

- PLX-PAD rescues blood flow in hind limb ischemia in a dose- and site-dependent manner.
- Live PLX-PAD cells are more efficacious than cell lysate.
- PLX-PAD secrete numerous pro-angiogenic factors.
- The proposed PLX-PAD mechanism of action involves multifactorial endocrine secretion.