کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8468168 1549571 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reiterative use of signalling pathways controls multiple cellular events during Drosophila posterior spiracle organogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Reiterative use of signalling pathways controls multiple cellular events during Drosophila posterior spiracle organogenesis
چکیده انگلیسی
Organogenesis proceeds in multiple steps and events that need to be coordinated in time and space. Yet the genetic and molecular control of such coordination remains poorly understood. In this study we have investigated the contribution of three signalling pathways, Wnt/Wingless (Wg), Hedgehog (Hh), and epidermal growth factor receptor (EGFR), to posterior spiracle morphogenesis, an organ that forms under Abdominal-B (AbdB) control in the eighth abdominal segment. Using targeted signalling inactivation, we show that these pathways are reiteratively used to control multiple cellular events during posterior spiracle organogenesis, including cell survival and maintenance of cell polarity and adhesion required for tissue integrity. We propose that the reiterative use of the Wg, Hh, and EGFR signalling pathways serves to coordinate in time and space the sequential deployment of events that collectively allow proper organogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 343, Issues 1–2, 1–15 July 2010, Pages 18-27
نویسندگان
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