Dynamics of Setdb1 expression in early mouse development

► We monitored Setdb1 expression during early mouse development. ► Setdb1 signals emerge as dots associated with the perinucleolar rims in zygotes. ► From 2-cell stage on, Setdb1 signals diffusely exist in the nucleus. ► In blastocyst and outgrowth, Setdb1 signals are found condensed foci. ► The varying expression patterns mean its involvement in diverse biological processes.