کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8471106 | 1550062 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of the expression of retinoic acid metabolising genes during Xenopus laevis organogenesis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Retinoic acid (RA) is a known teratogen that is also required endogenously for normal development of the embryo. RA can act as a morphogen, through direct binding to receptors and RA response elements in the genome, and classical studies of limb development and regeneration in amphibians have shown that it is likely to provide positional information. Availability of RA depends on both metabolic synthesis and catabolic degradation, and specific binding proteins act to further modulate the binding of RA to response elements. Here, we describe the expression of seven genes involved in metabolism (Raldh1-3), catabolism (Cyp26a and b) and binding of RA (Crabp1 and 2) during organogenesis in the clawed frog Xenopus laevis. Taken together, this data indicates regions of the embryo that could be affected by RA mediated patterning, and identifies some differences with other vertebrates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 11, Issues 1â2, JanuaryâFebruary 2011, Pages 112-117
Journal: Gene Expression Patterns - Volume 11, Issues 1â2, JanuaryâFebruary 2011, Pages 112-117
نویسندگان
Joshua Lynch, James McEwan, Caroline W. Beck,