Analyse protéomique du liquide amniotique

Amniotic fluid is a fundamental biological fluid for the development of the fetus. Many proteins of amniotic fluid are already present at a very early stage of gestation, whereas other proteins are detected only at the end of the pregnancy. The concentration of each amniotic fluid protein results from a balance between dynamic metabolisms and physiological processes. In this sense, proteomics that allows simultaneous study of a multitude of proteins may be of importance to gain insight into the physiology of this amniotic fluid as well as to identify potential markers of diseases during pregnancy. Here, we present a survey of recent proteomic studies on amniotic fluid and also some potential applications in health and diseases, being aware of proteomic tools' limitations.