کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8471946 1550143 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
La sensibilité dilutionnelle : reflet de la sensibilité analytique ? Impact sur les contrôles en sérologie virale
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
La sensibilité dilutionnelle : reflet de la sensibilité analytique ? Impact sur les contrôles en sérologie virale
چکیده انگلیسی
The analytical sensitivity represents the detection limit of a reagent, based on the smallest amount, obtained after dilutions, of the target marker that can be detected. In viral serology, reagents can screen one or several specificities. For single specific antigens or antibodies (presence of only one target marker) reagents, this dilutional sensitivity substantiates the analytical sensitivity which permits to compare a reagent with another one. For reagents which detect a number of antibody specificities (presence of several target markers), dilutional sensitivity does not allow to compare reagent sensitivities between them owing to the fact that the dilutional sensitivity is subordinated to the characteristics of the surface coating on one hand and the diluted sample on the other hand. This dilutional sensitivity, reagent and sample dependent, is the reason why it is difficult to prepare internal or external quality controls as well as panels which are adapted to all reagents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immuno-analyse & Biologie Spécialisée - Volume 21, Issue 5, October 2006, Pages 314-318
نویسندگان
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