کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8474790 1550432 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Redox-mediated signal transduction by cardiovascular Nox NADPH oxidases
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Redox-mediated signal transduction by cardiovascular Nox NADPH oxidases
چکیده انگلیسی
The only known function of the Nox family of NADPH oxidases is the production of reactive oxygen species (ROS). Some Nox enzymes show high tissue-specific expression and the ROS locally produced are required for synthesis of hormones or tissue components. In the cardiovascular system, Nox enzymes are low abundant and function as redox-modulators. By reacting with thiols, nitric oxide (NO) or trace metals, Nox-derived ROS elicit a plethora of cellular responses required for physiological growth factor signaling and the induction and adaptation to pathological processes. The interactions of Nox-derived ROS with signaling elements in the cardiovascular system are highly diverse and will be detailed in this article, which is part of a Special Issue entitled “Redox Signalling in the Cardiovascular System”.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 73, August 2014, Pages 70-79
نویسندگان
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