Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy

► Metabolomic analysis was done for hearts from hamsters with dilated cardiomyopathy. ► Disturbances in phospholipid homeostasis were initiated at pre-disease phase. ► Increased oxidative stress levels were suggested and confirmed at disease phase. ► Cardioprotective prostaglandin levels were increased at disease phase. ► Current metabolomic analysis provides mechanistic insights into DCM pathogenesis.