X-ROS signaling in the heart and skeletal muscle: Stretch-dependent local ROS regulates [Ca2Â +]i

► Review of the recently characterized stretch-dependent X-ROS signaling ► New tools are developed to stretch single cells. ► Stretch triggers the generation of reactive oxygen species (ROS). ► ROS regulate subcellular calcium signaling in the heart and skeletal muscle. ► X-ROS contributes to pathology in muscular dystrophy.