Mitochondrial aldehyde dehydrogenase 2 activation and cardioprotection

► PKCε activates ALDH2 and confers cardioprotection. ► ALDH2 overexpression antagonizes cardiac hypertrophy and failure. ► ALDH2 activation inhibits autophagy. ► ALDH2 activation reduces mitochondrial permeability. ► ALDH2 activation prevents arrhythmias.