کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8475633 | 1550457 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Individual condition and inflammatory response to PHA in the subterranean rodent Ctenomys talarum (Talas tuco-tuco): A multivariate approach
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کلمات کلیدی
PBSPLSPHATh1PhytohemagglutininRBCNaBSRBCFECRed blood cells - سلولهای قرمز خونNatural antibody - آنتی بادی طبیعیEosinophils - ائوزینوفیلهاParasite load - بار انگلPartial least squares regression - رگرسیون حداقل مربعات جزئیFecal egg count - شمارش تخم مرغphosphate buffered solution - محلول بافر فسفاتImmunity - مصونیتMonocytes - مونوسیتهاNeutrophil–lymphocyte ratio - نسبت نوروفیل لنفوسیتsheep red blood cells - گلبول های قرمز گوسفند
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Several components of individual condition can modulate immune function in vertebrates. One of the most common techniques used by ecologists to estimate immune responsiveness in wild populations is the phytohemagglutinin (PHA)-skin test, which is usually considered a proxy of cell- mediated activity. To determine the influence of individual condition on the magnitude of this immune index we assessed the variability in the inflammatory response to PHA in the subterranean solitary rodent, Ctenomys talarum (Talas tuco-tucos), including 18 variables associated with different aspects of individual condition that are indicative of physical, physiological, parasitological and immunological state. A partial least square (PLS) regression analysis was performed on the condition and the response variables to identify those having greater contribution to overall variation in the response. The first two components explained together 77.5% of the maximum achievable explained variance in the inflammatory response to PHA (60% of total variance). Abundance of eggs of Trichuris pampeana, eosinophil, monocyte and neutrophil counts, together with reproductive condition were identified as the most important variables affecting the inflammatory response. The first component negatively associated the inflammatory response to PHA with the abundance of the nematode T. pampeana, and with counts of eosinophils and monocytes. The second component negatively associated the inflammatory response to PHA with reproductive condition, neutrophils and eosinophils. We discuss the general negative effect of infection on the immune responsiveness of wild animals and highlight the usefulness of the multivariate approaches in providing information on physiology, parasitology and health relationships to assess patterns of variation in immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mammalian Biology - Volume 90, May 2018, Pages 47-54
Journal: Mammalian Biology - Volume 90, May 2018, Pages 47-54
نویسندگان
Julieta Leticia Merlo, Ana Paula Cutrera, Marcelo Javier Kittlein, Roxana Rita Zenuto,