Reduced cell number in the hindgut epithelium disrupts hindgut left-right asymmetry in a mutant of pebble, encoding a RhoGEF, in Drosophila embryos

► Pbl is required for the LR asymmetric development of the hindgut. ► Specification of hindgut tissues is normal in pbl homozygous embryos. ► Reduced cell number in the hindgut epithelium affects LR asymmetrical development of the embryonic hindgut.