کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8476390 1550808 2018 42 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The increase in fiber size in male rat gastrocnemius after chronic central leptin infusion is related to activation of insulin signaling
ترجمه فارسی عنوان
افزایش اندازه فیبر در گاستروکنیموس موش صحرایی پس از انفوزیون لپتین مزمن مرکزی به فعال شدن سیگنالینگ انسولین مربوط می شود
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
Insulin potentiates leptin effects on muscle accrual and glucose homeostasis. However, the relationship between leptin's central effects on peripheral insulin sensitivity and the associated structural changes remain unclear. We hypothesized that central leptin infusion modifies muscle size through activation of insulin signaling. Muscle insulin signaling, enzymes of fatty acid metabolism, mitochondrial respiratory chain complexes, proliferating cell nuclear antigen (PCNA) and fiber area were analyzed in the gastrocnemius of chronic central infused (L), pair-fed (PF) and control rats. PCNA-positive nuclei, fiber area, GLUT4 and glycogen levels and activation of Akt and mechanistic target of rapamycin were increased in L, with no changes in PF. Acetyl-CoA carboxylase-β mRNA levels and non-esterified fatty acid and triglyceride content were reduced and carnitine palmitoyltransferase-1b expression and mitochondrial complexes augmented in L. These results suggest that leptin promotes an increase in muscle size associated with improved insulin signaling favored by lipid profile.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 470, 15 July 2018, Pages 48-59
نویسندگان
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