Keywords: UCP2; uncoupling protein 2; PCLD; polycystic liver disease; PCKD; polycystic kidney disease; Mouse model; Mitochondria; Uncoupling protein 2 (UCP2); Polycystic liver disease (PCLD);
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Keywords: Genipin; Anticancer; UCP2; Metastasis; Crosslinking; Nano-formulations;
Keywords: Srebp1; Sterol regulatory element binding protein 1; Cd36; Cluster of differentiation 36; Ppar; Peroxisomal proliferator-activated receptor; Ucp2; Uncoupling protein 2; Socs3; STAT-induced suppressor of cytokine signaling 3; Fatp2/5; Fatty acid transporte
Keywords: NAFLD; non-alcoholic fatty liver disease; NAFL; non-alcoholic fatty liver; NASH; non-alcoholic steatohepatitis; mtDNA; mitochondrial DNA; FFAs; free fatty acids; TNF; tumor necrosis factor; CTRL; control; HF; high-fat; HF+HCh; high-fat+high-cholesterol; 7
Keywords: Runx2; Runt-related transcription factor-2; Osx; Oster; Alp; alkaline phosphatase; Col1a1; collagen type I alpha 1; Atf4; activating transcription factor 4; LDHA; lactate dehydrogenase A; PDK1; pyruvate dehydrogenase kinase 1; TCA; tricarboxylic acid; FND
Keywords: AgRP; agouti-related protein; AMPK; adenosin monophosphate activated protein kinase; AN; arcuate nucleus; As; arsenic; AraC; cytosine β-D-arabinofuranoside; BDNF; brain derived neurotrophic factor; BPA; bisphenol A; Ca; calcium; cDNA; complementary deoxy
Keywords: UCP2; Locomotor deficiency; Substantia nigra pars reticulata; Oxidative stress; Mitochondrial function; Hepatic encephalopathy;
Keywords: Butein (PubChem CID: 5281222); Cardamonin (PubChem CID: 641785); 2â²,4â²-Dihydroxy-6â²-methoxy-3â²,5â²-dimethylchalcone (PubChem CID: 10424762); Flavokawain B (PubChem CID: 5356121); Hydroxysafflor Yellow A (PubChem CID: 6443665); Naringenin Chalcone
Keywords: Gastrocnemius; Insulin signaling; Leptin; Mitochondrial respiratory chain; Proliferating cell nuclear antigen; Accβ; acetyl-CoA carboxylase beta; AMPK; AMP-activated protein kinase; Cpt1b; carnitine palmitoyltransferase 1b; CREB; cyclic AMP response elem
Keywords: Body weight; Food intake; Irisin; NPY; POMC; UCP2;
Keywords: BAK; BCL-2 antagonist killer; BAX; BCL-2 associated X protein; CDK1; cyclin dependent kinase 1; CLDN-6; claudin-6; CM; cardiomyocyte; CPE; Clostridium perfringens endotoxin; GPX2; glutathione peroxidase-2; GSH; glutathione; GSR; glutathione reductase; GSS
Keywords: Irisin; UCP2; UCP3; UCP4; UCP5; Rat brain; Body temperature;
Keywords: UCP2; Lifespan; Premature aging; Metabolism; Insulin/IGF-1 pathway;
Keywords: ALT; alanine aminotransferase; CM; cow milk; CPT; carnitine-palmitoyl-transferase; DM; donkey milk; FFA; free fatty acid; GSH; glutathione; GSSG; glutathione disulfide; GST; glutathione-S-transferase; HM; human milk; HOMA; homeostasis model assessment; IL
Keywords: Food timing; Leptin; Ghrelin; Adiponectin; Feeding behavior; Metabolic syndrome; ACC; acetyl CoA carboxylase; AdipoRS; adiponectin receptors; AgRP; agouti-related protein; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; AST; aspartate a
Keywords: C57BL/6 mice; Social stress; Obesity; Anxiety; White adipose tissue (WAT); Crh; Npy; Sgk1; Ucp2; Adrb1;
Keywords: Obesity; Hot water extract; High hydrostatic pressure extract; UCP2;
The beneficial effects of Gracilaria lemaneiformis polysaccharides on obesity and the gut microbiota in high fat diet-fed mice
Keywords: PPAR-γ; peroxisome proliferator-activated receptor-γ; UCP2; uncoupling protein 2; CPT-1α; carnitine palmitoyltransferase-1α; C/EBP; CCAAT/enhancer-binding protein; GPR41; G-protein-coupled receptor 41; GPR43; G-protein-coupled receptor 43; Polysacchar
Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
Keywords: ADH; alcohol dehydrogenase; ALD; Alcoholic liver disease; ALDH; aldehyde dehydrogenase; CPT-1α; carnitine palmitoyl transterase-1α; CR; calorie restriction; CS; citrate synthase; CYP2E1; cytochrome P450 2E1; FASN; fatty acid synthase; NAD+; nicotinamide
Scutellaria: Debates on the anticancer property
Keywords: Bcl-2; B-cell lymphoma 2; 5-FU; 5-Fluorouracil; TGF-β1; transforming growth factor beta 1; PTEN; phosphatase and tensin homolog; HIF-1α; hypoxia-inducible factor 1-alpha; MAPK; mitogen-activated protein kinase; CRC; cyclic redundancy check; SHH; sonic h
Relationship between estrogen and body composition, energy, and endocrine factors in obese women with normal and low REE
Keywords: Estrogen; UCP2; Leptin; Body composition; Food intake;
Fecal fermentation products of common bean-derived fiber inhibit C/EBPα and PPARγ expression and lipid accumulation but stimulate PPARδ and UCP2 expression in the adipogenesis of 3T3-L1 cells
Keywords: C/EBP; CCAAT/enhancer binding protein; FABP4; fatty acid binding protein 4; PPAR; peroxisome proliferator-activated receptor; SCFA; short-chain fatty acids; UCP2; mitochondrial uncoupling protein 2; Common beans; Adipogenesis; Fecal fermentation; Obesity;
Nellore bulls (Bos taurus indicus) with high residual feed intake have increased the expression of genes involved in oxidative phosphorylation in rumen epithelium
Keywords: 18S; 18S ribosomal RNA; ADG; average daily gain; AQP3, AQP7, AQP8, AQP10; aquaporins 3, 7, 8, and 10; ATP1B1, ATP1B2, ATP1B3; ATPase Na+/K+ transporting subunits beta 1, 2, and 3; ATP5H; ATP synthase; BDH1, BDH2; 3-hydroxybutyrate dehydrogenase 1 and 2; B
Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats
Keywords: Insulin resistance; Phosphorylated insulin receptor; p-Akt; GLUT2; Wnt pathway; Nrf2; Glutathione; UCP2;
Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms
Keywords: ABC; ATP-binding cassette; ABCA1; ATP-binding membrane cassette transporter A1; ABCG1; ATP binding cassette transporter G1; ABCA7; ATP-binding cassette transporters A7; Abs; Antibodies; ACs; Apoptotic cells; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ri
Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions
Keywords: AMPK; AMP-activated protein kinase; CaMKKβ; calcium/calmodulin-dependent protein kinase kinase beta; CBF; cerebral blood flow; CCA; common carotid artery; EBSS; glucose-free Earle's balanced salt solution; ECA; external carotid artery; ELISA; cytokine en
Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation
Keywords: FABP; Fatty acid binding protein; UCP2; uncoupling protein 2; PA; palmitic acid; ROS; reactive oxygen species; iNOS; inducible nitric oxide synthase; TNF-α; tumor necrosis factor alpha; Iba1; ionized calcium-binding adapter molecule 1; SFA; saturated fat
Mild palmitate treatment increases mitochondrial mass but does not affect EA.hy926 endothelial cells viability
Keywords: Endothelial cells; Inflammatory response; Mitochondrial mass; Palmitate; Reactive oxygen species; BSA; bovine serum albumin; Cu/Zn-SOD (SOD1); copper/zinc superoxide dismutase; eNOS; endothelial nitric oxide synthase; HUVEC; human umbilical vein endotheli
Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity
Keywords: Glucotoxicity; Oxidative stress; UCP2; Insulin secretion; Beta-cell; Pancreatic islet;
Mitochondrial Uncoupling Protein 2 in human cumulus cells is associated with regulating autophagy and apoptosis, maintaining gap junction integrity and progesterone synthesis
Keywords: Uncoupling Protein 2; Cumulus cells; Autophagy; Apoptosis; Gap junction; Progesterone synthesis; uncoupling Protein 2; UCP2; cumulus cells; CCs; adenosine triphosphate; ATP; adenosine diphosphate; ADP; reactive oxygen species; ROS; connexin 43; Cx43; glut
Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis
Keywords: ACM; alcoholic cardiomyopathy; ALDH; aldehyde dehydrogenase; ADH; alcohol dehydrogenase; PKC-β; protein kinase C (PKC)-beta; TCA cycle; tricarboxylic acid; ETC; electron transport chain; RCI; mitochondrial respiratory control index/ratio; FAD+; flavin ad
An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle
Keywords: CAT; catalase; COX; cytochrome c oxidase; DJ7; Parkinson 7; DNM1L; dynamin-1-like protein; FIS1; mitochondrial fission protein 1; MFF; mitochondrial fission factor; MFN1; mitofusin-1; MFN2; mitofusin-2; mtDNA; mitochondrial DNA; mtNOD; C57BL/6NTac-mtNODLt
UCP2 inhibition induces ROS/Akt/mTOR axis: Role of GAPDH nuclear translocation in genipin/everolimus anticancer synergism
Keywords: Pancreas cancer; Uncoupling proteins; UCP2; mTOR; Everolimus; GAPDH; Cell death;
Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
Keywords: Binge ethanol consumption; FGF21; Chronic ethanol consumption; Alcoholic liver disease; ACSS2; acyl-coenzyme a synthetase short-chain family member 2; ADH 1 and 2; alcohol dehydrogenase 1 and 2; ALDH1α1; aldehyde dehydrogenase 1 alpha 1; ALD; alcoholic l
Molecular mechanism of 18F-FDG uptake reduction induced by genipin in T47D cancer cell and role of uncoupling protein-2 in cancer cell glucose metabolism
Keywords: UCP2; Uncoupling; Genipin; ROS; MMP;
Mitochondria controlled by UCP2 determine hypoxia-induced synaptic remodeling in the cortex and hippocampus
Keywords: Perinatal hypoxia; Mitochondria; UCP2; Synaptic plasticity; Cortex; Hippocampus;
Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells
Keywords: SCFA; Microbiome; Autophagy; UCP2; ACTB; actin beta; ATP; adenosine triphosphate; MAP1LC3B; microtubule-associated protein 1 light chain 3B; PRKAA1; protein kinase, AMP-activated, alpha 1 catalytic subunit; SCFA; short-chain fatty acids; PPAR-γ; peroxiso
Leptin contributes to long-term stabilization of HIF-1α in cancer cells subjected to oxygen limiting conditions
Keywords: Obesity; Mitochondria; Uncoupled respiration; UCP2; SIRT1;
Research reportProtective effects of PGC-1α via the mitochondrial pathway in rat brains after intracerebral hemorrhage
Keywords: ICH; intracerebral hemorrhage; PGC-1α; Peroxisome proliferator activated receptor co-activator-1α; NRF1; Nuclear respiratory factor 1; Tfam; Mitochondrial transcription factor A; mtDNA; Mitochondrial DNA; UCP2; uncoupling protein 2; SOD2; superoxide dis
Oleic acid stimulates glucagon-like peptide-1 release from enteroendocrine cells by modulating cell respiration and glycolysis
Keywords: GLP-1; glucagon like peptide-1; OA; sodium salt of oleic acid; EC; enteroendocrine cells; GPR; G protein-coupled receptors; FAT; fatty acid transporters; CD36; class B scavenger receptor cluster-of-differentiation 36/fatty acid translocase; XF24; Seahorse
Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction
Keywords: PPARβ/δ; Endothelial dysfunction; UCP2; Oxidative stress; NADPH oxidase; ER stress;
The antioxidant uncoupling protein 2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreas cancer cells to glycolysis inhibition
Keywords: Cancer; Metabolism; Uncoupling proteins; UCP2; Warburg effect; Proteomics;
Transcriptional regulation analysis of FAM3A gene and its effect on adipocyte differentiation
Keywords: FAM3A; family with sequence similarity 3, member A; G6PD; glucose-6-phosphate dehydrogenase; PPARG(2); peroxisome proliferator-activated receptor gamma(2); C/EBPα; CCAAT/enhancer binding protein alpha; C/EBPβ(C/EBPβbeta); CCAAT/enhancer binding protein
Mitochondrial uncoupling protein (UCP2) gene expression is regulated by miR-2909
Keywords: AATF, Apoptosis Antagonizing Transcription Factor; UCP2, uncoupling protein 2Regulation; UCP2; CCL5; IL-17; AATF RNome
Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts
Keywords: CAC; citric acid cycle; DM2; type 2 diabetes mellitus; db/db; db/db mouse; FAO; fatty acid oxidation; ISC/REP; ischemia/reperfusion; LCFA; long chain fatty acid; MA; malate-aspartate shuttle; MHC-PPARα; myosin heavy chain-peroxisome proliferator activa
Peroxisome proliferator activated receptor-γ agonists protect oligodendrocyte progenitors against tumor necrosis factor-alpha-induced damage: Effects on mitochondrial functions and differentiation
Keywords: Oligodendrocytes; Multiple sclerosis; Mitochondria; TNF-α; PPAR-γ; UCP2; PGC-1α;
Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells
Keywords: Pancreatic beta cells; Glucolipotoxicity; Cytoprotection; Mitochondrial dysfunction; Uncoupling protein-2 (UCP2); Reactive oxygen species; INS-1E insulinoma cells; Non-esterified fatty acids; Obesity; Type 2 diabetes; BSA; bovine serum albumin; DAPI; 4â²
UCP2 inhibition sensitizes breast cancer cells to therapeutic agents by increasing oxidative stress
Keywords: Oxidative stress; UCP2; ROS; Cancer; Cisplatin; Tamoxifen; Autophagic cell death; Resistance;
Lung endothelial barrier protection by resveratrol involves inhibition of HMGB1 release and HMGB1-induced mitochondrial oxidative damage via an Nrf2-dependent mechanism
Keywords: HMGB1; high-mobility group box 1; VILI; ventilator-induced lung injury; LVT; low tidal volume; HVT; high tidal volume; MLVEC; mouse lung vascular endothelial cell; VE-cadherin; vascular endothelial cadherin; DAMP; damage-associated molecular pattern; ROS;
Mitochondrial UCP2 in the central regulation of metabolism
Keywords: UCP2; ghrelin; AgRP; POMC; hypothalamus; reward system; dopamine; synaptic plasticity; mitochondrial dynamics