کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8630575 1568815 2018 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum
ترجمه فارسی عنوان
تعاملات گیرنده های هورمون تیروئید و استروژن با لیگاندهای طبیعی و اختلال های غدد درون ریز در مخچه
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Although the effects of phytoestrogens on brain function is widely unknown, they are often regarded as “natural” and thus as harmless. However, the effects of phytoestrogens or environmental pollutants on brain function is underestimated. Estrogen (17beta-estradiol, E2) and thyroid hormones (THs) play pivotal roles in brain development. In the mature brain, these hormones regulate metabolism on cellular and organismal levels. Thus, E2 and THs do not only regulate the energy metabolism of the entire organism, but simultaneously also regulate important homeostatic parameters of neurons and glia in the CNS. It is, therefore, obvious that the mechanisms through which these hormones exert their effects are pleiotropic and include both intra- and intercellular actions. These hormonal mechanisms are versatile, and the experimental investigation of simultaneous hormone-induced mechanisms is technically challenging. In addition, the normal physiological settings of metabolic parameters depend on a plethora of interactions of the steroid hormones. In this review, we discuss conceptual and experimental aspects of the gonadal and thyroid hormones as they relate to in vitro models of the cerebellum.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Frontiers in Neuroendocrinology - Volume 48, January 2018, Pages 23-36
نویسندگان
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