کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6279639 1615081 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of central irisin administration on the uncoupling proteins in rat brain
ترجمه فارسی عنوان
اثرات تزریق مرکزی ایریسین بر پروتئین های جدا شده در مغز موش صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
It was observed that after application of the high dose irisin, UCP5 mRNA level in the all brain areas increased (p < 0.05); it was also observed that the three doses decreased the UCP4 expression in all brain areas (except the pituitary gland; p < 0.05). The UCP2 and UCP3 mRNA expressions showed significantly increase in cerebellum and striatum (p < 0.05). The UCP2 mRNA expression decreased in hypothalamus, pituitary gland, hippocampus and cortex areas (p < 0.05). It was also observed that the body temperatures of the rats increased depending on the irisin injection and this increase was the most considerable at the 24 h (p < 0.05). The results of this study suggest that the UCP2-5 is expressed in different areas of the brain, and the irisin affects this expression, and may have effective roles in some brain functions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 618, 8 April 2016, Pages 6-13
نویسندگان
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