کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8476732 | 1550843 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome
ترجمه فارسی عنوان
تومور فیبری انفرادی پانکراس سبب بروز سندرم هورمون افسردگی عصبی
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Solitary fibrous tumors occasionally present with hypoglycemia because of the excessive release of insulin-like growth factor II. We report the first case of pancreatic solitary fibrous tumor causing ectopic adrenocorticotropic hormone syndrome. An 82-year-old Japanese man presented with lower limb edema, uncontrolled hypertension, hypokalemia, and baseline hypercortisolism. Distal pancreatectomy was performed after the clinical diagnosis of a neuroendocrine tumor with ectopic secretion of adrenocorticotropic hormone. On histological examination, the tumor showed spindle cells in a fascicular arrangement. The diagnosis of the solitary fibrous tumor was confirmed by the identification of the NAB2-STAT6 fusion gene and positive immuno-histochemical staining for STAT6 and CD34. Using quantitative real-time polymerase chain reaction, mRNA that encoded proopiomelanocortin, precursor of adrenocorticotropic hormone, was detected. Proopiomelanocortin production through the demethylation of the promoter region Domain IV was detected. Pancreatic solitary fibrous tumors represent a new cause of ectopic adrenocorticotropic hormone syndrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 436, 15 November 2016, Pages 268-273
Journal: Molecular and Cellular Endocrinology - Volume 436, 15 November 2016, Pages 268-273
نویسندگان
Keigo Murakami, Yasuhiro Nakamura, Saulo J.A. Felizola, Ryo Morimoto, Fumitoshi Satoh, Kentaro Takanami, Hideki Katakami, Seiichi Hirota, Yoshiyu Takeda, Makiko Meguro-Horike, Shin-ichi Horike, Michiaki Unno, Hironobu Sasano,