The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1

- We discover SIRT1 activating compounds originated from oriental medicinal plants.
- Dehydroabietic acid could be a novel anti-aging compound and provide scientific evidences of the anti-aging effects.
- Aging model organism, C. elegans lifespan extension effect of dehydroabietic acid is due to direct binding and activating SIRT1.
- Dehydroabietic acid prevents age-related pigment, lipofuscin accumulation in human dermal fibroblast.
- We propose a direct binding model for dehydroabietic acid and SIRT1.