STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition

- hSTC1 is a cAMP signaling inhibitor.
- hSTC1 and hCGRP peptides activate distinct signaling pathways.
- hSTC1 promotes CGRP receptor assembly during osteoblastogenesis.
- hSTC1 in vivo inhibits hCT, but not hCGRP, cAMP signaling.