کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8477457 | 1550903 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus
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کلمات کلیدی
GnRHHPGGSIOVXORFPFAGnIHEstradiol - استرادیولSpexin - اسپکسینOvariectomy - اوفورکتومی، تخمدان برداریImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیReproduction - تولید مثل یا زادآوریgonadosomatic index - شاخص گنادوسوماتیکopen reading frame - قاب خواندن بازNeuropeptide - نوروپپتیدgonadotropin releasing hormone - هورمون آزاد کننده گنادوتروپینfollicle stimulating hormone - هورمون تحریک کننده فولیکولluteinizing hormone - هورمون جسم زردFSH - هورمون محرکه فولیکولی Gonadotropin-inhibitory hormone - هورمون مهارکننده گنادوتروپینbody weight - وزن بدنgerminal vesicle - ویسکوز ژرمینالparaformaldehyde - پارافرمالدهید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus A novel neuropeptide in suppressing luteinizing hormone release in goldfish, Carassius auratus](/preview/png/8477457.png)
چکیده انگلیسی
The fish reproductive axis is regulated by many neuroendocrine factors. However, factors involved in the suppression of this axis are largely uncharacterized. In this study, we describe a novel neuropeptide derived from the spexin precursor acting as a negative factor to suppress the reproductive axis in teleost. The cDNA sequences of the spexin precursors have been cloned from both zebrafish and goldfish. A 14-aa mature peptide with the C-terminal amidated (spexin-14a: NWTPQAMLYLKGTQ-NH2) is conceivably generated by processing of the spexin precursors in both species. Spexin is mainly expressed in the brain and ovary of zebrafish and spexin-14a-ir cells are located in several brain regions of goldfish. Functionally, goldfish spexin-14a could significantly suppress luteinizing hormone (LH) release in cultured goldfish pituitary cells. Moreover, intraperitoneal injection of spexin-14a could effectively suppress serum LH level. The mRNA expression of spexin is lower in the breeding season and hypothalamic expression of spexin is regulated by gonadal hormones. These results constitute the first report on the novel role of spexin in the negative regulation of the reproductive axis in teleost.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 374, Issues 1â2, 15 July 2013, Pages 65-72
Journal: Molecular and Cellular Endocrinology - Volume 374, Issues 1â2, 15 July 2013, Pages 65-72
نویسندگان
Yun Liu, Shuisheng Li, Xing Qi, Wenyi Zhou, Xiaochun Liu, Haoran Lin, Yong Zhang, Christopher H.K. Cheng,