Regulation of adrenocortical steroid hormone production by RhoA-diaphanous 1 signaling and the cytoskeleton

► ACTH/cAMP-stimulated adrenocortical steroidogenesis is regulated by the cytoskeleton. ► ACTH increases cortisol production via a RhoA-DIAPH1-dependent pathway. ► ER-mitochondria tethering may facilitate substrate transfer between organelles.