Diastereomeric mixture of calophyllic acid and isocalophyllic acid stimulates glucose uptake in skeletal muscle cells: Involvement of PI-3-Kinase- and ERK1/2-dependent pathways

► The diastereomeric mixture (F015) stimulates glucose uptake in muscle cells. ► F015 enhances translocation of GLUT4 to plasma membrane in skeletal muscle cells. ► F015 exerts the biological effects via PI-3-K and ERK1/2-dependent mechanisms. ► F015 improves glucose tolerance and insulin sensitivity in insulin resistant mice.