AU-rich elements in the 3′-UTR regulate the stability of the 141 amino acid isoform of parathyroid hormone-related protein mRNA

► The instability of PTHrP 1-141 mRNA is determined by four AREs in its 3′-UTR. ► Effects of these AREs are potentially mediated by the tristetraproline (TTP) ARE-binding protein. ► Additional proteins (60-80 kDa) bind specifically to the AREs in HARA cell extracts.