Interleukin-6: A multifunctional targetable cytokine in human prostate cancer

► Interleukin-6 is a multifunctional cytokine which regulates growth of prostate cancer. ► Stimulation of androgen receptor activity by interleukin-6 may enhance or inhibit proliferation. ► Interleukin-6 inhibits apoptosis in several prostate cancer cell lines. ► Suppressor of cytokine signalling-3 is expressed in prostate cancer. ► Antibody CNTO 328 (Anti IL-6) was tested in preclinical research and clinical trials.