Sequences that direct subcellular traffic of the Drosophila methoprene-tolerant protein (MET) are located predominantly in the PAS domains

► We ask what elements affect subcellular traffic of methoprene-tolerant protein (MET). ► We identify mosaic of both nuclear localization signals and nuclear export signals. ► Subcellular localization of MET depends on combined contribution of various signals. ► The activity of PAS-B nuclear localization signal is controlled by juvenile hormone.