Keywords: biopharmaceuticals characterization; surfactants; protein formulation; NMR spectroscopy; protein aggregation; API; active pharmaceutical ingredient; D2O; deuterated water, heavy water, deuterium oxide; JP; Japanese Pharmacopeia; NMR; nuclear magnetic reso
مقالات ISI (ترجمه نشده)
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Keywords: ASD; amorphous solid dispersion; AUC; area under the curve; C; supersaturated concentration of CUR; CSat; saturation solubility of CUR; CE; complexation efficiency; CHI; chitosan; CUR; curcumin; DLS; dynamic light scattering; DSC; differential scanning ca
Keywords: AAC; area above the curve; CDI; N,Nʹ-carbonyldiimidazole; CH; cholesterol; CH-Lip; conventional (cholesterol) liposomes; DMAP; dimethylaminopyridine; DMF; dimethylformamide; EDC; N-ethyl-Nʹ-(3-dimethylaminopropyl) carbodiimide; EE; entrapment efficiency
Keywords: Whey protein; In vitro digestion; Bioactive peptide; Glucagon-like peptide-1; Dipeptidyl peptidase IV inhibitor; Antioxidant activity; α-LA; α-lactalbumin; β-LG; β-lactoglobulin; ABAP; 2,2â²-azobis(2-methylpropionamidine) dihydrochloride; AMC; H-Gly-
Keywords: freeze-drying/lyophilization; formulation; protein delivery; mucosal drug delivery; stabilization; solid dosage form; solid state stability; BP; British Pharmacopoeia; CG; carrageenan; EC50; half-maximal effective concentration; FDI; fast-dissolving inser
Keywords: 2D-LC; Two Dimensional Liquid Chromatography; ADC; Antibody Drug Conjugate; AEX; Anion Exchange Chromatography; BEH; Bridged Ethylene Hybrid (hybrid silica); BSA; Bovine Serum Albumin; BsAb; Bispecific Antibody; CQA; Critical Quality Attribute; EMA; Europ
Keywords: AMMS; accurate mass spectrometry; AQbD; analytical quality-by-design; ASME; American Society of Mechanical Engineers; ATP; analytical target profile; CQA; critical quality attributes; DoE; design of experiments; DQ; design qualification; DS; design space;
Keywords: BCA; bicinchoninic acid; CV; coefficient of variation; EDTA; ethylenediaminetetraacetic acid; ESI; electrospray ionization; FDA; Food and Drug Administration; fu; free drug fraction; LC-MS/MS; liquid chromatography, tandem mass spectrometry; LLOQ; lower
Keywords: 5α-adiol; 5α-androstan-3α,17β-diol; 5β-adiol; 5β-androstan-3α,17β-diol; A; androsterone; ANOVA; analysis of variance; AUC; area under the curve; CV%; coefficient of variation; CV; cross validation; DA; discriminant analysis; DHEA; dehydroepiandros
Keywords: Salts; Gemfibrozil; Intrinsic dissolution rate; Surface dissolution imaging; Focus variation; GEM; gemfibrozil; DSC; differential scanning calorimetry; XRPD; X-ray powder diffraction; API; active pharmaceutical ingredient; BCS; biopharmaceutical classific
Keywords: Ub; ubiquitin; UBLs; ubiquitin-like proteins; DUBs; deubiquitinating enzymes; TCR; T cell receptor; UPS; ubiquitin-proteasome system; IAPs; inhibitors of apoptosis-related proteins; GAPs; GTPase-activating proteins; PI3K; phosphatidylinositol 3-kinase;
Keywords: Akt2; RAC-β serine/threonine-protein kinase; AR; aldose reductase; Bcl-2; B-cell lymphoma 2; CFL1; cofilin 1;; cMDH1; cytosolic NAD-dependent malate dehydrogenase 1; CTSK; cathepsin K; Cu-Zn SOD; Cu/Zn superoxide dismutase; DHAR2; dehydroascorbate reduct
Keywords: PEDV; Papain-like protease; 6-Thioguanine; Noncompetitive inhibition; Alpha coronavirus; AUC; The abbreviations used are analytical ultracentrifugation; CoV; coronavirus; DUB; deubiquitinating; MERS; Middle East respiratory syndrome; βME; β-mercaptoetha
Keywords: [Emim][BF4]; ethyl-methylimidazolium tetrafluoroborate; [Omim][BF4]; octyl-methylimidazolium tetrafluoroborate; [Bmim][BF4]; butyl-methylimidazolium tetrafluoroborate; [Emim][TfO]; ethyl-methylimidazolium trifluoromethanesulfonate; [Pmim][TfO]; propyl-met
Keywords: container closure integrity testing; prefilled syringe; primary packaging; mass spectrometry-based helium leak detection; USP <1207>; CCI; container closure integrity; CCS; container closure system; CCIT; container closure integrity testing; DIN; Deutsche
Keywords: A4D; adapter 4 dialysis; API; active pharmaceutical ingredient; DLS; dynamic light scattering; EP; European Pharmacopoeia; FaSSGF; fasted state simulated gastric fluid; FaSSIF; fasted state simulated intestinal fluid; FaSSIF-V2; fasted state simulated int
Keywords: Degradation products; Impurities; International chemical reference substances; Pharmacopoeial standards; Reference standards; Primary reference standards; Secondary reference standards; Working standards; AAS; atomic absorption spectroscopy; ANDA; abbrevi
One single, fast and robust capillary electrophoresis method for the direct quantification of intact adenovirus particles in upstream and downstream processing samples
Keywords: Ad26; adenovirus serotype 26; Ad35; adenovirus serotype 35; Ad5; adenovirus serotype 5; AEX; anion exchange product; AEX-HPLC; anion exchange HPLC; AQbD; analytical quality by design; ATP; analytical target profile; CH; clarified harvest; CR; crude harves
Keywords: ADB; Asian Development Bank; AusAID; Australian Agency for International Development; FAO; Food and Agriculture Organisation (UN); FICS; Forum (Secretariat) Island Country States; FAD; Fish Aggregating Device; HIE; Household Income and Expenditure; IAS; I
Keywords: ADB; Asian Development Bank; BAU; business as usual; COP; Conference of the Parties; CROP; Council of Regional Organisations in the Pacific; EC; European Commission; EU; European Union; FAESP; Framework for Action on Energy Security in the Pacific; FATS;
Keywords: Alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS, PubChem CID:71406); Cisplatin (PubChem CID:441203); Distearoyl phosphoethanolamine polyethylene glycol 2000, sodium salt (DSPE-mPEG-2000, PubChem CID:86278270); l-leucine (PubChem CID: 6106); d-ma
Keywords: PTM; post-translational modification; RBR; RING-between-RING; DUB; deubiquitinase; USP; ubiquitin-specific protease; SCF; Skp1-Cullin-F-box; CaMKII; Ca2Â +/calmodulin-dependent kinase 2; Cbl; Casitas B-lineage lymphoma; TKB; tyrosine kinase binding; RTK;
Keywords: salt; solubility; pH; dissolution; poorly water soluble; solution phase; solid phase; equilibrium; salt dissociation; phase-transformation; API; active pharmaceutical ingredient; AUC; area under curve; Cmax; maximum concentration; FaSSIF; fasted state sim
Keywords: amorphous; nanoparticles; nanocrystalline; solubility; stability; dissolution; solid state; calorimetry; X-ray diffraction; bioavailability; ACN; amorphous chitin nanoparticles; API; active pharmaceutical ingredient; APTES; 3-aminopropyltriethoxysilane; B
Keywords: SA; sodium alginate; M-block; β-d-mannuronic acid unit of SA; G-blocks; α-l-guluronic acid unit of SA; CL; calcium lactate; RVS; reverse spherification; LHB; liquid-core hydrogel beads; RBJ; radish by-product juice; MAFF; Ministry of Agriculture, Forest
Keywords: OD; osmotic dehydration; ST; static osmotic dehydration; AG; osmotic dehydration with agitation; USP; osmotic dehydration with ultrasound pretreatment; US; osmotic dehydration with ultrasound application; Effective diffusivity; Osmotic dehydration; Potato
Keywords: AAA; ATPases associated with diverse cellular activities; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ABC; ATP-binding cassette; ABCE1; ATP binding cassette subfamily E member 1; AD; Alzheimer's disease; AIF; apoptosis inducing factor; Akt; Alpha se
Keywords: AC; activated carbon; ACS; American Chemical Society; FAME; fatty acid methyl ester; FCC; Food Chemical Codex; FFA; free fatty acid; FID; flame ionization detector; FTIR; Fourier transform infrared; GC; gas chromatography; MONG; matter organic non glycero
Keywords: ADHD; attention hyperactive disorder; AKT; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; Bcl-2; B-cell lymphoma 2; BDNF; brain derived neurotrophic factor; Css; Steady state plasma concentration; D1; type 1 dopamine recept
Keywords: AT; antithrombin; BSA; bovine serum albumin; CTA; cetyltrimethylammonium; Gal; galactose; GlcA; glucuronic acid; LMWH; low-molecular-weight heparin; NMR; nuclear magnetic resonance; SAX; strong anion exchange; USP; United States Pharmacopeia; Enoxaparin s
Keywords: API; Active Pharmaceutical Ingredient; EDQM; European Directorate for the Quality of Medicines and HealthCare; GMP; Good Manufacturing Practices; IPC; In Process Control; LF-NMR; Low-Field NMR spectroscopy; MEDS; Mission for Essential Drugs and Supplies;
Keywords: Preeclampsia; eclampsia; magnesium sulphate; chemical stability; CL2; commercially available lidocaine HCl 2%; CM50; commercially available magnesium sulphate 50%; CM50CL2; commercially available magnesium sulphate 50% combined with lidocaine; HPLC; high
Keywords: KAAD; Catholics Academics Ausländer-Dienst; BfArM; Bundesinstut für Arzneimeittel und Medizinprodukte; TFDA; Tanzania Food and Drugs Authority; QC; quality control; API; active pharmaceutical ingredient; RP-HPLC; reverse phase- high performance liquid c
Keywords: 2D-LC; two-dimensional liquid chromatography; AA; amino acid; AC; affinity chromatography; ADC; antibody-drug conjugates; ADCC; antibody-dependent cellular cytotoxicity; AF4; asymmetric flow field fractionation; APTS; 1-aminopyrene-3,6,8-trisulfonate; Asn
Keywords: siRNA; small interfering ribonucleic acid; Pt; platinum; PBS; phosphate buffered saline; PDMS; polydimethylsiloxane; PEG; polyethylene glycol; USP; United States Pharmacopeia; SL; stereolithography; EI; electrochemical impedance; Drug delivery; Wireless p
Keywords: ACGIH; American Conference of Industrial Hygienists; AP; acidification potential; ATP; aquatic toxicity potential; ATPE; aqueous two-phase extraction; CIP; cleaning in place; CO; carbon oxides; CO2; carbon dioxide; EDTA; ethylenediaminetetraacetic acid; E
Keywords: CMC; Regulatory; Cell therapy; CAT; Committee for Advanced Therapies; CCIT; container closure integrity test; CFR; Code of Federal Regulations; CLIA; Clinical Laboratory Improvement Amendments; CMC; Chemistry Manufacturing and Controls; CPMP; Committee fo
Keywords: Cell therapy; Minimally manipulated; Homologous use; Health Canada; Food and Drugs Act; Food and Drug Regulations; AHR Act; Assisted Human Reproduction Act of Canada; BGTD; Biologics and Genetic Therapies Directorate; CBER; Center for Biologics Evaluation
Keywords: BCS; Biopharmaceutics Classification System; CIP; ciprofloxacin; CV; coefficient of variation; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EDTA; trypsin-ethylenediaminetetraacetic acid; FESEM; field emission scanning electron
Keywords: DSC; Differential Scanning Calorimetry; FDM; Fused Deposition Modelling; FFF; Fused filament fabrication; SEM; Scanning Electron Microscopy; HME; Hot Melt Extrusion; HPC; hydroxypropyl cellulose; PVA; polyvinyl alcohol; TEC; triethyl citrate; TGA; Thermo
Keywords: API; Active Pharmaceutical Ingredient; NSDS; Nipple Shield Delivery System; USP; United States Pharmacopeia; Rapidly disintegrating tablet; Texture analysis; Infant drug delivery; Breast milk; Nipple shield delivery system; NSDS;
Keywords: Tooth extraction; diabetes mellitus; infection; wound healing; hyperglycemia; HbA1c; Glycated hemoglobin; Ig; Immunoglobulin; USP; University of São Paulo;
Keywords: HPMC; hydroxypropyl methylcellulose; GG; native grewia gum; GDS; starch-free grewia gum; GGp; native grewia gum polymer; GDSp; de-starched grewia gum polymer; HPMCp; hydroxypropyl methylcellulose polymer; HPMCf; hydroxypropyl methylcellulose formulation;
Keywords: SUT; single-use technology; CMOs; contract manufacturing organisation(s); mAb; monoclonal antibody; BSL; biosafety level; CIP; cleaning-in-place; SIP; sterilisation-in-place; WFI; water for injection; DSP; downstream processing; CHO; Chinese hamster ovary
Keywords: AFNOR; Association Française de Normalisation; AED; Atomic emission detector; ANRT; Association Nationale de la Recherche et de la Technologie; BS; British Standard; DSC; Differential scanning calorimetry; EFSA; European Food Safety Authority; EO; Essent
Keywords: 5-FU; 5-fluorouracil; API; active pharmaceutical ingredient; ADA; anti-drug antibodies; CSE; control standard endotoxin; CTL; cytotoxic T lymphocytes; CARPA; complement activation-related pseudoallergy; CHAPS; 3-[(3-Cholamidopropyl)dimethylammonio]-1-;
Keywords: AI-1; alpha-1 inulin; AI-2; alpha-2 inulin; BP; British Pharmacopoeia; DI; delta inulin; EI; epsilon inulin; FRM; filtered raw material (methods); GI; gamma inulin; MPI; microparticulate inulin; NA; not applicable; ND; not determined; OI; omega inulin; PB
Keywords: AV; acceptance value; CIJC; confined impinging jet crystallization; DLS; dynamic light scattering; DSC; differential scanning calorimetry; ESC; encapsulation by spray coagulation; NP; nanopharmaceutical; PXRD; powder X-ray diffraction; SDS; sodium dodecyl
Keywords: ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph
Keywords: BAC; Blood alcohol content; B-BAES; Brief Biphasic Alcohol Effects Scale; CO; Carbon monoxide; DDS; dependent daily smokers; FTCD; Fagerström test for Cigarette Dependence; NNS; nondependent nondaily smokers; NRT; nicotine replacement therapy; QSU-Brief;